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A. K. Wahi , J. Ravi , S. Hemalatha , P. N. Singh

Abstract

Objective : The evaluation of antidiabetic activity of alcoholic and aqueous extracts of whole plant of Daemia extensa R Br. Materials and methods: The antidiabetic activity of both the extracts were evaluated using alloxan (120 mg/kg; i.p.) induced hyperglycemic rats. The potency of alcoholic and aqueous extracts were compared with that of reference drug chlopropamide. The blood glucose level was measured by using glucometer. Results: The alcoholic extract produced a highly significant fall in Blood Glucose Level (BGL) at 1 h after a single dose of the extract and in prolong treatment (i.e. for a week) the antidiabetic activity was maintained at par with the reference drug chlopropamide. Aqueous extract possess antidiabetic activity which was maintained upto 3 hours after a single dose and later the activity decreases but upon prolonged treatment, the peak activity was found on second day. Conclusion: Alcoholic extract of D. extensa is almost equipotent to chlorpropamide. This qualifies it to be used in ethnomedical diabetic management.

Keywords

Daemia extensa, Anti-diabetic Activity, Alloxan

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M. Geetha , A. K. Wahi

Abstract

Objective: To study antidiabetic effect of various parts of B. prionitis. Materials and methods: Antidiabetic activity of B. prionitis was evaluated using alloxan induced hyperglycemic rats. The potency of alcoholic and aqueous extracts of leaf, stem and ischolar_main was compared with that of chlorpropamide at a dose of 200 and 100mg/kg respectively. The blood glucose level was measured colorimetrically. Results: Alcoholic&aqueous extracts of leaf and ischolar_main caused significant fall in blood glucose level in diabetic rats. Conclusion: B. prionitis is almost equipotent to chlorpropamide in its ability to reduce the sugar levels and can be recommended for further studies.

Keywords

Barleria Prionitis, Antidiabetic Activity, Alloxan

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R. C. Gupta ¹, A. K. Wahi ¹

Affiliations
1 National Botanical Research Institute, Lucknow, IN

Abstract

The present paper deals with the macro- and micro-Scopical studies of the vegetative parts of Sarcostemma brevistigma W.&A. The cell-contents, percentage extractives and ash values, fluorescence characters and behaviour of drug powder on treatment with different chemical reagents is also described.

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Tripathi Kishu ¹, Kumar T. Siva ², A. K. Wahi ³

Affiliations
1 Institute of Pharmaceutical Sciences & Research Center, Bhagwant University, Ajmer, Rajasthan, IN
2 Nandha College of Pharmacy, Tamil Nadu, IN
3 Gyani Inder Singh Institute of Professional Studies, Dehradun, IN

Abstract

Cholic acid and metal ions both have antibacterial activity; therefore, their organometallic complexes were prepared to have synergistic effect. Cholic acid is one of the lead molecules for preparing organometallic complexes and their complexes were found to have more active anticancer activity.

Keywords

Cholic Acid, Organometallic Complexes.

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